Ph. D. Project
Contribution of traumatic vulnerability to epileptogenesis and to the occurrence of epileptic and psychogenic non-epileptic seizures
2020/10/01 - 2023/09/30
Other supervisor(s):
The psychotraumatic dimension is a key aspect to understand the epileptic and psychogenic non-epileptic seizures (PNES). The principal aim of this
research is to explore the complex and multidirectional interactions between the psychological trauma, epileptic seizures and PNES. The current study also
intends to shed light on the explanatory factors of psychotraumatic impact on the occurrence of the epileptic seizures (epileptogenesis) and investigate the
possible explanations for the co-occurrence of epileptic seizures and PNES. A cohort of 300 patients will be created based on the already existing data and
the data which will be collected prospectively through a standardized procedure. Different neurological, traumatic, psychiatric and psychological factors will
be explored in order to respond three main study purpose: The contribution of a traumatic experience to epileptogenesis, the impact of trauma on the
occurrence of epileptic and psychogenic non-epileptic seizures and the possible interrelationship between epilepsy and PNES based on traumatic
experience. The results of this study will provide an important etiopathogenic comprehension of these two pathologies and also provide a clinical
understating particularly on the traumatic dimension.
Epilepsy, Stress, Psychogenic non-epileptic seizures, Psychological trauma, Psychiatric comorbidity
3 years
Collaboration : the CHRU Nancy La Teppe establishment
Psychiatrist , Psychologist or neuropsychologist

- The first year will be devoted to the characterization of the multidisciplinary data set to be gathered on this cohort, to start the inclusions and to conduct a
systematic review of the literature.
- The second year will be devoted to finalizing the database with a target of 300 patients.
- The third year will be devoted to the production of scientific articles.

Translated with (free version)
Biology, Signals and Systems in Cancer and Neuroscience
Research unit of La Teppe de Tain L'hermitage