BioSiS - Systems, Ionizing Radiations & Nanomedicine in Neuro-Oncology (SyRaNNO)

The SyRaNNO project is part of the field of neuro-oncology, with primary and secondary brain tumors as its target applications. Based on the multidisciplinary skills of the team members (clinicians, biologists, physicists and numerical analysts), this project aims to better understand, predict and control the cellular plasticity and dynamics of tumors in the brain environment, when they are subjected to standard treatments (combining surgery, radiotherapy and chemotherapy) or innovative therapeutic strategies. We are more specifically interested in: optimizing innovative therapies that include ionizing radiation (particularly associated with inorganic nanoparticles), based on an integrative dosimetry (physical, biochemical and biological) for better tumor control; developing digital and mathematical tools capable of modeling phenomena at the molecular, cellular or tissue scales to account for tumor progression and treatment response. To achieve our objectives, we rely on existing technical platforms (histology, molecular biology, cell biology...) and on the BioSiS department's platforms (OptiRad, PhotoVivo).